International Journal of Pharma and Bio Sciences SESAME MEAL ADMINISTRATION ATTENUATE THE HIGH-FAT DIET INDUCED LIPID ABNORMALITIES AND IMPROVE INSULIN SENSITIVITY IN WISTAR RATS ANITHA U AND R. KARUPPASAMY

Obesity and lipid metabolism abnormalities are associated with numerous non communicable diseases such as metabolic syndrome, type2 diabetes, arthrosclerosis, fatty liver diseases, infertility etc. Modern life style choices such as consumption of high caloric diet and sedentary living conditions are implicated in the pathogenesis of these diseases. Most of the currently available drugs for these diseases are either ineffective or causing numerous side effects. The western lifestyle choices have intruded into every corner of the world. As the people started to adapt to the westernized food and lifestyle, the traditional and indigenous customs, foods of the local areas are being forgotten from the human mind. Sesame is one such dietary ingredient used in the Indian culinary from time immemorial. Consumption of sesame, sesame oil and food prepared from sesame meal is practiced for long time and possess several medicinal values. Sesame meal in particular is assumed to possess weight reducing effects in humans. In the present study, the sesame meal was administered to the wistar rats fed with high-fat diet and their protective roles were compared with pioglitazone. After 13 weeks of sesame and pioglitazone treatment on high-fat diet fed rat, the changes in the lipid profile such as fasting insulin, glucose, triglycerides, total cholesterol, Low Density Lipoprotein, High Density Lipoprotein, Free Fatty Acid levels were measured. A comparison of the performance of sesame meal in the respect of lipid abnormalities on high fat diet rat clearly indicates that the changes of lipid profiles are improved towards the normal level. All these effects were also comparable to that of pioglitazone treated rats. BIO CHEMISTRY